Synlett 2013; 24(6): 666-685
DOI: 10.1055/s-0032-1318222
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© Georg Thieme Verlag Stuttgart · New York

Efficiency, Diversity, and Complexity with Multicomponent Reactions

Gydo van der Heijden
Department of Chemistry and Pharmaceutical Sciences, Amsterdam Institute of Molecules, Medicines and Systems, VU University Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands   Fax: +31(20)5987488   Email: [email protected]   Email: [email protected]
,
Eelco Ruijter*
Department of Chemistry and Pharmaceutical Sciences, Amsterdam Institute of Molecules, Medicines and Systems, VU University Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands   Fax: +31(20)5987488   Email: [email protected]   Email: [email protected]
,
Romano V. A. Orru*
Department of Chemistry and Pharmaceutical Sciences, Amsterdam Institute of Molecules, Medicines and Systems, VU University Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands   Fax: +31(20)5987488   Email: [email protected]   Email: [email protected]
› Author Affiliations
Further Information

Publication History

Received: 18 December 2012

Accepted after revision: 22 January 2013

Publication Date:
08 March 2013 (online)


Abstract

Multicomponent reactions (MCRs) are versatile syntheses for obtaining structurally diverse sets of complex scaffolds with high efficiency. As such, they can be attractive synthetic tools for the realization of diversity- and/or biology-oriented synthesis design strategies for focused libraries. In this account, we present an overview of our contribution to the design of novel MCRs to access a high level of molecular complexity and diversity. In addition, we demonstrate our biocatalysis/MCR sequences to obtain stereoenriched product scaffolds.

1 Introduction

2 The Build/Couple/Pair Strategy

3 Rational Design of Multicomponent Reactions

3.1 Single Reactant Replacement

3.2 Modular Reaction Sequences

3.3 Conditions-Based Divergence

3.4 The Combination of Multicomponent Reactions

4 Palladium-Catalyzed Isocyanide Reactions

5 The Quest for Stereoselective Multicomponent Reactions

6 Conclusion

 
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