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Synthesis 2013; 45(19): 2699-2705
DOI: 10.1055/s-0033-1338419
DOI: 10.1055/s-0033-1338419
special topic
Reductive Cyclizations of Nitroarenes to Hydroxamic Acids by Visible Light Photoredox Catalysis
Further Information
Publication History
Received: 01 March 2013
Accepted: 17 March 2013
Publication Date:
24 April 2013 (online)
Abstract
We have developed a photocatalytic reduction of nitroarenes as an efficient, chemoselective route to biologically important N-phenyl hydroxamic acid scaffolds. Optimal conditions call for 2.5 mol% of a ruthenium photocatalyst, visible light irradiation, and a dihydropyridine terminal reductant. Because of the mild nature of the visible light activation, functional groups that might be sensitive to other non-photochemical reduction methods are easily tolerated.
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- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
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