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Synthesis 2014; 46(14): 1853-1858
DOI: 10.1055/s-0033-1339109
DOI: 10.1055/s-0033-1339109
special topic
Synthesis of α-Ketoamides from Aryl Methyl Ketones and N,N-Dimethylformamide via Copper-Catalyzed Aerobic Oxidative Coupling
Further Information
Publication History
Received: 23 February 2014
Accepted after revision: 13 April 2014
Publication Date:
28 May 2014 (online)
Abstract
A copper-catalyzed aerobic oxidative coupling of aryl methyl ketones with N,N-dimethylformamide was developed, which afforded α-ketoamides by a sequence of dioxygen activation, C–H bond functionalization, and amide formation with N,N-dimethylformamide as the nitrogen source. Molecular oxygen was found to play a crucial role in this transformation.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/products/ejournals/journal/ 10.1055/s-00000084.
- Supporting Information
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