Synlett 2013; 24(13): 1599-1605
DOI: 10.1055/s-0033-1339284
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© Georg Thieme Verlag Stuttgart · New York

Recent Developments in the Synthesis of Bioactive 2,4,6-Trisubstituted 1,3,5-Triazines

Ranjan Banerjee
Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, MA 02467, USA   Fax: +1(617)5522705   Email: eranthie@bc.edu
,
Douglas R. Brown
Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, MA 02467, USA   Fax: +1(617)5522705   Email: eranthie@bc.edu
,
Eranthie Weerapana*
Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, MA 02467, USA   Fax: +1(617)5522705   Email: eranthie@bc.edu
› Author Affiliations
Further Information

Publication History

Received: 14 May 2013

Accepted after revision: 23 May 2013

Publication Date:
27 June 2013 (online)

Abstract

1,3,5-Triazine derivatives have widespread applications in the pharmaceutical, material, and agrochemical industries. In the biological arena, small-molecule libraries of 2,4,6-trisubstituted 1,3,5-triazines have yielded selective and potent chemical probes for diverse protein families. The structural symmetry and ease of functionalization of the 1,3,5-triazine core renders it a powerful scaffold for the rapid generation of diverse molecular libraries. Numerous synthetic routes, both solid-phase and solution-phase, have been developed to arrive at alkyl/aryl amino- and oxy-substituted triazine libraries. Here, we feature a subset of the recent synthetic advances towards generating 2,4,6-trisubstituted 1,3,5-triazines and highlight biologically active compounds that have resulted from these endeavors.

 
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