Synlett 2013; 24(15): 1882-1886
DOI: 10.1055/s-0033-1339684
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© Georg Thieme Verlag Stuttgart · New York

Development and Challenges in the Copper-Catalyzed Trifluoromethylation of Alkenes

Xiaowu Liu
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Guangzhou 510530, P. R. of China   Fax: +86(20)32093615   Email: wu_xiaoxing@gibh.ac.cn
,
Xiaoxing Wu*
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Guangzhou 510530, P. R. of China   Fax: +86(20)32093615   Email: wu_xiaoxing@gibh.ac.cn
› Author Affiliations
Further Information

Publication History

Received: 07 July 2013

Accepted after revision: 09 August 2013

Publication Date:
22 August 2013 (online)

Abstract

The recent trifluoromethylation of unactivated alkenes and related compounds provides a new and straightforward method to mainly form Csp3–CF3 bonds. However, several mechanisms have been proposed for the system of copper catalysts and electrophilic trifluoromethylating reagents. This paper differentiated the radical mechanism from others experimentally and computationally by investigating the chemoselectivity in the rearrangement of unsymmetrical α,α-diaryl allylic alcohols. Moreover, it outlines some future directions in this field.

 
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