Synlett 2013; 24(19): 2472-2476
DOI: 10.1055/s-0033-1339871
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© Georg Thieme Verlag Stuttgart · New York

Pd-Catalyzed sp2 C–H Hydroxylation with TFA/TFAA via Weak Coordina­tions

Yu Rao*
MOE Key Laboratory of Protein Sciences, Department of Pharmacology and Pharmaceutical Sciences, School of Medicine and School of Life Sciences, Tsinghua University, Beijing 100084, P. R. of China   Fax: +86(10)62783404   Email: yrao@tsinghua.edu.cn
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Further Information

Publication History

Received: 14 June 2013

Accepted after revision: 30 August 2013

Publication Date:
30 September 2013 (online)

Abstract

An efficient sp2 C–H hydroxylation has been developed for the synthesis of a wide range of functionalized phenols with aryl ketones, benzoates, benzamides, acetanilides and sulfonamides through palladium(II) catalysis. A trifluoroacetic acid (TFA)/trifluoroacetic anhydride (TFAA) co-solvent system serves as the oxygen source and is the critical factor for weak coordination promoted C–H activation.

 
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