Synlett 2014; 25(14): 1946-1952
DOI: 10.1055/s-0033-1340194
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© Georg Thieme Verlag Stuttgart · New York

Hydrodefluorination of Perfluoroarenes Meets Visible Light Photocatalysis

Jimmie D. Weaver*
Further Information

Publication History

Received: 09 April 2014

Accepted after revision: 30 April 2014

Publication Date:
23 May 2014 (eFirst)

Abstract

Partially fluorinated arenes are increasingly found in pharmaceuticals, agrochemicals and materials. While interest in these molecules is high, the number of available methods for their syntheses is severely limited. While installation of a single fluorine is achievable, installation of several fluorines represents a significant challenge. Approaching this synthetic problem from the opposite direction has been more fruitful. Specifically, by subjecting perfluorinated arenes to selective hydrodefluorination the desired molecules can be obtained. Herein, the advancement of this approach is discussed.

 
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