Synthesis 2014; 46(08): 1030-1045
DOI: 10.1055/s-0033-1341052
short review
© Georg Thieme Verlag Stuttgart · New York

Glycosylation Reactions in the Synthesis of Flavonoid Glycosides

Jiansong Sun
a   State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, P. R. of China   Fax: +86(21)64166128   Email: byu@mail.sioc.ac.cn
,
Stéphane Laval
b   ICMMO/G2M/LCOM, UMR 8182 (CNRS-UPS), LabEx LERMIT, Université Paris-Sud, 91405 Orsay Cedex, France
,
Biao Yu*
a   State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, P. R. of China   Fax: +86(21)64166128   Email: byu@mail.sioc.ac.cn
› Author Affiliations
Further Information

Publication History

Received: 23 December 2013

Accepted after revision: 03 March 2014

Publication Date:
20 March 2014 (online)


Abstract

An overview of flavonoid glycoside synthesis has been provided with an emphasis on the construction of the glycosidic linkages.

1 Introduction

2 Synthetic Tactics

3 Synthesis of Flavonoid O-Glycosides

3.1 Glycosylation with Glycosyl Bromides

3.2 Glycosylation with Glycosyl Imidates

3.3 Glycosylation with Glycosyl Esters

3.4 Glycosylation with Glycosyl Fluorides

3.5 Combined Application of Different Types of Glycosyl Donors­

4 Synthesis of Flavonoid C-Glycosides

5 Synthesis of Flavonoid Mixed O,C-Glycosides

6 Conclusion

 
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