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Synthesis 2014; 46(20): 2763-2770
DOI: 10.1055/s-0034-1378522
DOI: 10.1055/s-0034-1378522
paper
A New Method for Thiomethylation of Hydroxy-1,4-naphthoquinones with N-Acetyl-l-cysteine; First Synthesis of Fibrostatins B, C, and D
Further Information
Publication History
Received: 21 April 2014
Accepted after revision: 24 June 2014
Publication Date:
30 July 2014 (online)
Abstract
A series of N-acetyl-S-[(3-hydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methyl]-l-cysteine conjugates were obtained in good yields by acid-catalyzed condensation of substituted 2-hydroxy-1,4-naphthoquinones with N-acetyl-l-cysteine and paraformaldehyde. Based on this reaction, a first synthesis of fibrostatins B, C, and D was developed.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/products/ejournals/journal/ 10.1055/s-00000084.
- Supporting Information
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