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Planta Med 2015; 81 - PX16
Antitrypanosomal activity of an iridal from Iris domestica and initial structure-activity relationships
The myristate ester of iso-iridogermanal was identified as an antitrypanosomal component of Iris domestica using bioassay-guided fractionation. This compound has previously been isolated from I. domestica, as well as other Iris species, and has been shown to be cytotoxic to tumor cells. Investigation of the antitrypanosomal activity of iso-iridogermanal, as well as semi-synthetic derivatives, will be presented.