Echinochlorins A˜C from the grains of Echinochloa utilis (Barnyard Millet) and their anti-inflammatory activity

MH Woo; DH Nguyen; BT Zhao; UM Seo; TT Nguyen; DY Jun; YH Kim

doi:10.1055/s-0035-1556510

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Planta Med 2015; 81 - PX66
DOI: 10.1055/s-0035-1556510

Echinochlorins A˜C from the grains of Echinochloa utilis (Barnyard Millet) and their anti-inflammatory activity

MH Woo ¹, DH Nguyen ¹, BT Zhao ¹, UM Seo ¹, TT Nguyen ¹, DY Jun ², YH Kim ²

¹College of Pharmacy, Catholic University of Daegu, Gyeongsan 712 – 702, Republic of Korea
²Laboratory of Immunobiology, School of Life Science and Biotechnology, College of Natural Sciences, Kyungpook National University, Daegu 702 – 701, Republic of Korea

Congress Abstract

Three new compounds (echinochlorins A-C; 1, 8, and 9) together with eight known compounds, isolated form the methylene chloride and ethyl acetate fractions of grains of Echinochloa utilis, were examined with regard to their effect on nitric oxide (NO) production in lipopolysaccharide (LPS)-activated murine macrophage RAW 264.7 cells. The results indicated that compounds 3, 5, and 9 possessed potent NO inhibitory activity against lipopolysaccharide (LPS)-induced NO release with IC₅₀ values of 36.04, 4.80, and 20.78µM, respectively. In summary, the isolates compounds showed novel biological activity of inhibition in NO production, suggesting that E. utilis may be applied as supplemental functional foods having a beneficial effect against inflammation.