Synlett 2016; 27(06): 805-813
DOI: 10.1055/s-0035-1560551
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© Georg Thieme Verlag Stuttgart · New York

Employing Unnatural Amino Acids in the Preparation of Biooconjugates

Johnathan C. Maza
Department of Chemistry, College of William & Mary, P.O. Box 8795 Williamsburg, Virginia, 23187, USA   Email: dyoung01@wm.edu
,
Taylor H. Jacobs
Department of Chemistry, College of William & Mary, P.O. Box 8795 Williamsburg, Virginia, 23187, USA   Email: dyoung01@wm.edu
,
Diya M. Uthappa
Department of Chemistry, College of William & Mary, P.O. Box 8795 Williamsburg, Virginia, 23187, USA   Email: dyoung01@wm.edu
,
Douglas D. Young*
Department of Chemistry, College of William & Mary, P.O. Box 8795 Williamsburg, Virginia, 23187, USA   Email: dyoung01@wm.edu
› Author Affiliations
Further Information

Publication History

Received: 14 September 2015

Accepted after revision: 04 November 2015

Publication Date:
04 January 2016 (online)

Abstract

The exploitation of unnatural amino acid (UAA) technologies represents an excellent mechanism for the generation of site-specific bioconjugates. Consequently, significant effort has been invested in the advancement of the technology via the integration of novel bioconjugation reactions and the expansion of the set of UAAs that can be employed. Herein, we report the recent developments in the field and highlight advantages and disadvantages of various UAA bioconjugation reactions.

 
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