Synlett 2016; 27(05): 641-649
DOI: 10.1055/s-0035-1561270
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© Georg Thieme Verlag Stuttgart · New York

Structure-Based Drug Design in Medicinal Chemistry: The Devil is in the Detail

Maren Kuhnert
Institut für Pharmazeutische Chemie, Philipps-Universität Marburg, Hans-Meerwein-Straße 3, 35043 Marburg, Germany   Email: wibke.diederich@staff.uni-marburg.de
,
Wibke E. Diederich*
Institut für Pharmazeutische Chemie, Philipps-Universität Marburg, Hans-Meerwein-Straße 3, 35043 Marburg, Germany   Email: wibke.diederich@staff.uni-marburg.de
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Further Information

Publication History

Received: 12 August 2015

Accepted after revision: 28 October 2015

Publication Date:
04 January 2016 (online)

Abstract

Structure-based drug design (SBDD) has become an important concept in medicinal chemistry, and the hypothesis that similar ligands bind in a similar fashion is widely accepted within the medicinal chemistry community. However, there are a number of interesting case studies, some of which are discussed in detail, which highlight that this does not hold true on a comprehensive basis.

 
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