Reductive Cyclization of 1,6- and 1,7-Enynes Catalyzed by Iron Complexes

Abstract

Iron-catalyzed reductive cyclization of 1,6- and 1,7-enynes was demonstrated by using an oxazoline iminopyridine ligand. Alcohol, ketone, ester, ether, halide, amine, amide, imine, nitrile, silyl, and alkyne groups are tolerated under the mild reaction conditions. A speculative mechanism is proposed on the basis of deuteration studies. A primary enantioselective transformation was also conducted.

Key words

iron - catalysis - enynes - cyclizations - asymmetric synthesis

• References


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