Regioselective Ylide Formation on Acetal-Functionalized Trialkyl Phosphonium Salts: Extending the Scope of Carbonyl HomologationWe thank the Natural Sciences and Engineering Research Council of Canada (NSERC), Solvay-Cytec Canada, Inc., the Ontario Centres of Excellence, and Connect Canada for financial support of this work.
Received: 29 June 2017
Accepted after revision: 22 July 2017
22 August 2017 (eFirst)
Dedicated to Professor Victor Snieckus on the occasion of his 80th birthday
The discovery of a complex-induced proximity effect and scope of regioselective ylide formation on acetal- and ketal-functionalized trialkylphosphine-derived phosphonium salts is explored as a route to homologated unsaturated carbonyl derivatives.