Asymmetric Total Synthesis of (+)-Minfiensine by an Asymmetric Cascade Cyclization StrategyFinancial support from the National Natural Science Foundation of China (Grant No. 21502102) and the Thousand Talents Plan for Young Professionals is acknowledged.
Received: 27 May 2017
Accepted after revision: 19 June 2017
25 August 2017 (eFirst)
The Strychnos alkaloid minfiensine and a series of akuammiline alkaloids, such as vincorine, aspidophylline A, and picrinine, possess a common core skeleton, a 4a,9a-heterocycle-fused tetrahydrocarbazole. Efficient construction of this core structure in a highly enantioselective manner would facilitate the total synthesis of these alkaloids. In this article, we briefly summarize the established strategies for obtaining this core structure, together with the corresponding total-synthesis routes, and we describe our own effort on the development of a new strategy, the asymmetric cascade dearomative cyclization, for the efficient total synthesis of (+)-minfiensine.