Synlett 2017; 28(11): 1237-1243
DOI: 10.1055/s-0036-1590202
synpacts
© Georg Thieme Verlag Stuttgart · New York

Copper-Catalyzed Oxidation of Alkanes under Mild Conditions

Isaac Garcia-Bosch*
Department of Chemistry, Southern Methodist University, Dallas, Texas 75275, USA   Email: igarciabosch@smu.edu
› Author Affiliations
Further Information

Publication History

Received: 21 January 2017

Accepted after revision: 28 February 2017

Publication Date:
23 March 2017 (online)

Abstract

The selective functionalization of C–H bonds is a critical step in the majority of synthetic organic pathways. Our research lab, among others, takes inspiration from the reactivity of Cu-dependent metalloenzymes to design catalytic systems for the C–H oxidation of challenging substrates (i.e., alkanes). In this Synpacts article, we summarize our recent findings on the Cu-catalyzed peroxidation of C–H bonds with H2O2 under mild conditions.

 
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