Diastereoselective Palladium-Catalyzed Conjugate Addition of Arylboronic Acids to α-Substituted Cyclic EnonesThe authors acknowledge financial support from the National Natural Science Foundation of China (NSFC) (21532010, 21372242, 21472214, 21421091), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB20030100), the NSFC and the Research Grants Council of Hong Kong Joint Research Scheme (21361162001), the Technology Commission of Shanghai Municipality, and the Croucher Foundation of Hong Kong.
Received: 22 May 2017
Accepted after revision: 05 July 2017
23 August 2017 (eFirst)
This paper is dedicated to Professor Victor Snieckus on the occasion of his 80th birthday.
A palladium-catalyzed conjugate addition of arylboronic acids to α-substituted cyclic enones was developed to give α,β-disubstituted ketones with high diastereoselectivity. Mechanistic investigation showed that the high diastereoselectivity was realized through epimerization.