The Transient Directing Group Strategy: A New Trend in Transition-Metal-Catalyzed C–H Bond FunctionalizationThis work was partially supported by INSA Rouen, Rouen University, CNRS, EFRD, Labex SynOrg (ANR-11-LABX-0029) and Région Normandie (Crunch Network). Q. Z. thanks the CSC (China Scholarship Council) for a doctoral fellowship.
Received: 12 July 2017
Accepted: 14 July 2017
23 August 2017 (eFirst)
In recent years, the C–H bond activation field has known very fast expansion offering valuable synthetic tools. Consequently, the quest for new approaches to afford atom- and step-economical processes has driven the scientific community to imagine original strategies. In this context, the direct functionalization of substrates by a transition-metal-catalyzed C–H bond activation using a transient directing group has emerged as a promising approach. This short review focuses on the major progress made in this field to provide to the reader an overview of the recent advances.
2 From a Historical Point of View
3 Functionalization of Carbonyl Derivatives
4 Functionalization of Amines Derivatives
5 Summary and Outlook