Synthesis
DOI: 10.1055/s-0036-1590878
short review
© Georg Thieme Verlag Stuttgart · New York

The Transient Directing Group Strategy: A New Trend in Transition-Metal-Catalyzed C–H Bond Functionalization

Qun Zhao, Thomas Poisson, Xavier Pannecoucke, Tatiana Besset*
This work was partially supported by INSA Rouen, Rouen University, CNRS, EFRD, Labex SynOrg (ANR-11-LABX-0029) and Région Normandie­ (Crunch Network). Q. Z. thanks the CSC (China Scholarship Council) for a doctoral fellowship.
Further Information

Publication History

Received: 12 July 2017

Accepted: 14 July 2017

Publication Date:
23 August 2017 (eFirst)

Abstract

In recent years, the C–H bond activation field has known very fast expansion offering valuable synthetic tools. Consequently, the quest for new approaches to afford atom- and step-economical processes has driven the scientific community to imagine original strategies. In this context, the direct functionalization of substrates by a transition-metal-catalyzed C–H bond activation using a transient directing group has emerged as a promising approach. This short review focuses on the major progress made in this field to provide to the reader an overview of the recent advances.

1 Introduction

2 From a Historical Point of View

3 Functionalization of Carbonyl Derivatives

4 Functionalization of Amines Derivatives

5 Summary and Outlook