Synthesis 2017; 49(24): 5380-5386
DOI: 10.1055/s-0036-1590897
paper
© Georg Thieme Verlag Stuttgart · New York

Highly Selective Approach to α-Iodoketones from Aminoalkynols with Iodine Monochloride

Vijay V. Raoa, b, Nedaossadat Mirzadeha, Suresh Bhargava*a, Pravin R. Likhar*c
  • aCenter for Advanced Materials and Industrial Chemistry, School of Applied Sciences, RMIT University, 124 LaTrobe Street, Melbourne VIC 3000, Australia   Email: suresh.bhargava@rmit.edu.au
  • bIICT-RMIT Joint Research Center, CSIR-IICT, Uppal Road, Tarnaka, Hyderabad 500007, India
  • cOrganometallic Gp., I & P C Division, CSIR-IICT, Uppal Road, Tarnaka, Hyderabad 500007, India   Email: plikhar@iict.res.in
Further Information

Publication History

Received: 22 July 2017

Accepted after revision: 04 August 2017

Publication Date:
31 August 2017 (eFirst)

Abstract

A protocol has been developed to achieve selective and direct synthesis of α-iodoketones under mild condition, from the reaction of aminoalkynols with iodine monochloride. The scope of the reaction was investigated using various aminoalkynols with iodine monochloride and the corresponding α-iodoketones were obtained selectively without forming iodocyclized and/or addition products.

Supporting Information

 
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