Directing Methylene Oxidation towards Azaheterocycles by Transition-Metal and Organic Catalysis

Abstract

A combination of transition-metal and organic catalysis has been used to deliver a system that can selectively oxidize benzylic methylene groups adjacent to azaheterocycles in preference to other positions that are typically more reactive. Here, we provide more background and context that describes what inspired our approach to catalyst development.

1 Introduction

2 Site-Selective Methylene Oxidation

3 Literature Inspiration for Design Plan

4 Combined Ligand/Metal/HAT Catalyst Effects

5 Perspectives for Future Work

Key words

site selectivity - hydrogen atom transfer - iron - oxidation - synergistic catalysis - heterocycles

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