Synthesis 2018; 50(17): 3387-3394
DOI: 10.1055/s-0037-1609844
special topic
© Georg Thieme Verlag Stuttgart · New York

Photoredox-Catalyzed Radical Relay Reaction Toward Functionalized Vicinal Diamines

Xiao-De An
State Key Laboratory of Analytical Chemistry for Life Science, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China   eMail: yushouyun@nju.edu.cn
,
State Key Laboratory of Analytical Chemistry for Life Science, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China   eMail: yushouyun@nju.edu.cn
› Institutsangaben

The National Natural Science Foundation of China (21472084, 21672098 and 21732003).
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Publikationsverlauf

Received: 03. März 2018

Accepted after revision: 09. April 2018

Publikationsdatum:
20. Juni 2018 (online)


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Published as part of the Special Topic Photoredox Methods and their Strategic Applications in Synthesis

Abstract

A strategy has been described to synthesize β,γ-diamino­ketones. This strategy is enabled by photoredox-catalyzed and nitrogen-centered radical-triggered cascade reactions of styrenes, enamides, and O-acylhydroxylamines in DMSO. Four bonds (one C–C, one C–N, and two C–O) are constructed in a single operation. Various functionalized vicinal diamines have been furnished by the radical relay reaction.

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