Abstract
A simple protocol, which is catalyst-free, metal-free, and chemoselective, for transamidation
of activated secondary amides in ethanol as solvent under mild conditions is reported.
A wide range of amines, amino acids, amino alcohols, and the substituents, which are
problematic in catalyzed transamidation, are tolerated in this methodology. The transamidation
reaction was successfully extended to water as the medium as well. The present methodology
appears to be better than the other catalyzed transamidations reported recently.
Keywords
amino acid - catalyst-free - metal-free - chemoselective - secondary amide - transamidation
