Synthesis 2019; 51(03): 643-663
DOI: 10.1055/s-0037-1610852
short review
© Georg Thieme Verlag Stuttgart · New York

Recent Developments in Palladium-Catalysed Non-Directed C–H Bond Activation in Arenes

a   Department of Chemistry, Bioscience and Environmental Technology, Faculty of Science and Technology, University of Stavanger, P.O. Box 8600 Forus, N-4036 Stavanger, Norway   Email: kare.b.jorgensen@uis.no
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a   Department of Chemistry, Bioscience and Environmental Technology, Faculty of Science and Technology, University of Stavanger, P.O. Box 8600 Forus, N-4036 Stavanger, Norway   Email: kare.b.jorgensen@uis.no
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b   Van’t Hoff Institute for Molecular Sciences, University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The Netherlands   Email: m.a.fernandezibanez@uva.nl
› Author Affiliations

This work was supported by an EU COST ACTION CA15106 (CHAOS) STSM grant and a UiS Research Mobility grant.
Further Information

Publication History

Received: 17 September 2018

Accepted after revision: 17 October 2018

Publication Date:
08 January 2019 (online)


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Abstract

Over the past decades, organic chemists have focussed on developing new approaches to directed C–H functionalisations, where the site selectivity is steered by the presence of a directing group (DG). Nonetheless, in recent years, more and more non-directed strategies are being developed to circumvent the requisite directing group, making C–H functionalisations more generic. This short review focuses on the latest developments in palladium-catalysed non-directed C–H functionalisations of aromatic compounds.

1 Introduction

2 C–C Bond Formation

2.1 C–H Arylation

2.2 C–H Alkylation

2.3 C–H Alkenylation

2.4 C–H Carbonylation

3 C–Heteroatom Bond Formation

3.1 C–O Bond Formation

3.2 C–N Bond Formation

3.3 C–S Bond Formation

4 Conclusion