Synthesis, Inhaltsverzeichnis Synthesis 2019; 51(12): 2506-2514DOI: 10.1055/s-0037-1611795 special topic © Georg Thieme Verlag Stuttgart · New YorkRuthenium-Catalyzed Annulation of N-Cbz Hydrazones via C–H/N–N Bond Activation for the Rapid Synthesis of Isoquinolines Authors Institutsangaben Dewal S. Deshmukh Bhalchandra M. Bhanage* Department of Chemistry, Institute of Chemical Technology, N. Parekh Marg, Matunga, Mumbai 400 019, India eMail: bm.bhanage@gmail.com eMail: bm.bhanage@ictmumbai.edu.in Artikel empfehlen Abstract Alle Artikel dieser Rubrik(opens in new window) Published as part of the Special Topic Ruthenium in Organic Synthesis Abstract In this work, N-Cbz hydrazone has been employed as a rarely explored directing group for the synthesis of isoquinolines by annulation with internal alkynes via C–H/N–N activation using Ru catalyst. Additive as well as external oxidant-free rapid protocol has been established for the synthesis of isoquinolines using microwave strategy. Use of non-volatile and biodegradable PEG as a green solvent with lower catalyst loading makes the proposed protocol environmentally benign. Further, higher functional group tolerance and wide substrate scope has been observed under the stated methodology with higher yields. Key words Key wordsC–H/N–N activation - ruthenium - microwave-assisted - isoquinolines - annulation - hydrazones Volltext Referenzen References 1a Dyker G. Angew. Chem. Int. Ed. 1999; 38: 1698 1b Yamaguchi J, Yamaguchi AD, Itami K. Angew. Chem. Int. Ed. 2012; 51: 8960 1c Chen DY.-K, Youn SW. Chem. Eur. J. 2012; 18: 9452 1d Kuhl N, Hopkinson MN, Wencel-Delord J, Glorius F. Angew. Chem. Int. Ed. 2012; 51: 10236 1e Engle KM, Mei T.-S, Wasa M, Yu J.-Q. Acc. Chem. Res. 2012; 45: 788 1f McMurray L, O’Hara F, Gaunt MJ. Chem. Soc. Rev. 2011; 40: 1885 1g Cho SH, Kim JY, Kwak J, Chang S. Chem. Soc. Rev. 2011; 40: 5068 1h Wencel-Delord J, Dröge T, Liu F, Glorius F. Chem. Soc. Rev. 2011; 40: 4740 1i Lyons T, Sanford M. Chem. 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