Synthesis 2020; 52(21): 3211-3218
DOI: 10.1055/s-0040-1707124
special topic
© Georg Thieme Verlag Stuttgart · New York

Step-Economical C–H Activation Reactions Directed by In Situ Amidation

Baoli Zhao
a  College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, P. R. of China   Email: chemliuyunyun@jxnu.edu.cn
b  Institute of Applied Chemistry and Department of Chemistry, Shaoxing University, Shaoxing, Zhejiang Province 312000, P. R. of China
,
Yunyun Liu
a  College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, P. R. of China   Email: chemliuyunyun@jxnu.edu.cn
› Author Affiliations
This work is supported by the National Natural Science Foundation of China (Grant No. 21562024).
Further Information

Publication History

Received: 31 March 2020

Accepted after revision: 27 April 2020

Publication Date:
18 May 2020 (online)


Published as part of the Special Topic Recent Advances in Amide Bond Formation

Abstract

Owing to the inherent ability of amides to chelate transition-metal catalysts, amide-directed C–H activation reactions constitute a major tactic in directed C–H activation reactions. While the conventional procedures for these reactions usually involve prior preparation and purification of amide substrates before the C–H activation, the step economy is actually undermined by the operation of installing the directing group (DG) and related substrate purification. In this context, directed C–H activation via in situ amidation of the crude material provides a new protocol that can significantly enhance the step economy of amide-directed C–H activation. In this short review, the advances in C–H bond activation reactions mediated or initiated by in situ amidation are summarized and analyzed.

1 Introduction

2 In Situ Amidation in Aryl C–H Bond Activation

3 In Situ Amidation in Alkyl C–H Bond Activation

4 Annulation Reactions via Amidation-Mediated C–H Activation

5 Remote C–H Activation Mediated by Amidation

6 Conclusion

 
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