Abstract
Vicinal difluorinated alkanes are entities relevant to medicinal chemistry that are
accessed through the difluorination of alkenes. This reaction has advanced from the
use of highly reactive and unsafe reagents, which provide poor functional-group tolerance
and selectivity, to the use of safer and more selective reagents that facilitate access
to a broader scope of substrates. In this review article, we describe the details
of these developments.
1 Introduction
2 Strategy 1: Ambiphilic Fluorine Sources
3 Strategy 2: Oxidant and Fluoride
4 Conclusions and Outlook
Key words
fluorination - alkenes - oxidation - hypervalent iodine - electrochemistry - difluorination
