Nickel-Catalyzed Multicomponent Coupling Reaction of Alkyl Halides, Isocyanides and H2O: An Expedient Way to Access Alkyl Amides

Qiao Li; Hongwei Jin; Yunkui Liu; Bingwei Zhou

doi:10.1055/s-0040-1707229

Synthesis, Inhaltsverzeichnis

Synthesis 2020; 52(22): 3466-3472
DOI: 10.1055/s-0040-1707229

paper

Nickel-Catalyzed Multicomponent Coupling Reaction of Alkyl Halides, Isocyanides and H₂O: An Expedient Way to Access Alkyl Amides

Qiao Li

,

Hongwei Jin

,

Yunkui Liu∗

College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, P. R. of China eMail: ykuiliu@zjut.edu.cn eMail: zhoubw@zjut.edu.cn

,

Bingwei Zhou ∗

College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, P. R. of China eMail: ykuiliu@zjut.edu.cn eMail: zhoubw@zjut.edu.cn

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Abstract

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Abstract

We herein describe a Ni-catalyzed multicomponent coupling reaction of alkyl halides, isocyanides, and H₂O to access alkyl amides. Bench-stable NiCl₂(dppp) is competent to initiate this transformation under mild reaction conditions, thus allowing easy operation and adding practical value. Substrate scope studies revealed a broad functional group tolerance and generality of primary and secondary alkyl halides in this protocol. A plausible catalytic cycle via a SET process is proposed based on preliminary experiments and previous literature.

Key words

nickel catalysis - isocyanide - alkyl halides - multicomponent coupling reaction - amide

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Referenzen

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