Synthesis 2022; 54(19): 4294-4303
DOI: 10.1055/s-0041-1737546
special topic
SYNTHESIS Conference Special Topic ISySyCat21

Photocatalytic Approach to α,α-Difluoroalkyl Alcohols

Georgii Kachkovskyi
a   Selvita SA., Bobrzyńskiego 14, 30-348 Kraków, Poland
,
Marcin Cieślak
a   Selvita SA., Bobrzyńskiego 14, 30-348 Kraków, Poland
,
Piotr Graczyk
a   Selvita SA., Bobrzyńskiego 14, 30-348 Kraków, Poland
,
Przemysław Zawadzki
a   Selvita SA., Bobrzyńskiego 14, 30-348 Kraków, Poland
,
Justyna Kalinowska-Tłuścik
b   Faculty of Chemistry Jagiellonian University, Gronostajowa 2, 30-387 Krakow, Poland
,
a   Selvita SA., Bobrzyńskiego 14, 30-348 Kraków, Poland
b   Faculty of Chemistry Jagiellonian University, Gronostajowa 2, 30-387 Krakow, Poland
› Author Affiliations
This work was financed by Regional Operational Programme for the Małopolska Region 2014–2020 (Project no. RPMP.01.02.01-12-0681/ 16-00 co-financed by the European Union) and Selvita.


Abstract

A convenient approach to previously poorly accessible α,α-difluoroalkyl alcohols by visible light-mediated photocatalysis was developed. Broad scope of the transformation together with experimental simplicity and scalability using flow techniques open good prospects for further studies of properties (including biological) of these novel products.

Supporting Information



Publication History

Received: 30 November 2021

Accepted after revision: 14 January 2022

Article published online:
16 March 2022

© 2022. Thieme. All rights reserved

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