Diterpenoid Alkaloids from Delphinium ajacis and Their Anti-RSV Activities

Abstract

Five new diterpenoid alkaloids, ajacisines A–E (1–5), were isolated from Delphinium ajacis, along with seven known alkaloids (6–12). On the basis of their spectral data (IR, UV, HR-ESI-MS, 1D and 2D NMR) and chemical properties, the structures of compounds 1–12 were identified. All isolated compounds were evaluated for their in vitro antiviral activities against respiratory syncytial virus, and compounds 3–5 and 8 exhibited moderate to weak effects with IC₅₀ values of 75.2 ± 1.1, 35.1 ± 0.6, 10.1 ± 0.3, and 50.2 ± 0.5 µM, respectively.

Key words

Delphinium ajacis - Ranunculaceae - diterpenoid alkaloid - anti-RSV activity

• References

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