Dearomatization of α-Unsubstituted β-Naphthols

Abstract

This Account summarizes the highly appealing dearomatization reactions of β-naphthols for the synthesis of highly functionalized, three-dimensional structures starting with simple planar aromatic compounds. The reactions are categorized mainly from the viewpoint of the construction of carbon–hydrogen, carbon–carbon, and carbon–hetero bonds (C–N/O, C–Cl, C–F) at the α-position of β-naphthols. The dearomatized products play an important role in organic synthesis and materials science.

1 Introduction

2 Construction of Carbon–Hydrogen Bonds at the α-Position of β-Naphthols

3 Construction of Carbon–Carbon Bonds at the α-Position of β-Naphthols

4 Construction of Carbon–Nitrogen/Oxygen Double Bond at the α-Position of β-Naphthols

5 Construction of Carbon–Carbon and Carbon–Oxygen Bonds at the α-Position of β-Naphthols

6 Construction of Carbon–Halogen Bonds at the α-Position of β-Naphthols

7 Conclusion

Key words

β-naphthol - dearomatization - naphthalen-2-one

Publication History

Received: 15 September 2023

Accepted after revision: 05 October 2023

Article published online:
10 November 2023

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