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Synthesis 1990; 1990(8): 735-738
DOI: 10.1055/s-1990-27000
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Hydrolysis of N-Substituted Phthalimides Using Anion Exchange Resins. Synthesis of Hydroxy-Substituted Aliphatic Primary Amines (Amino Alcohols)

Naohiro Kuriyama* , Yoshiharu Inoue, Keishi Kitagawa
  • *YMC Co. Ltd., 249 Mori Murahigashi, Kumiyama-cho, Kuse-gun, Kyoto 613, Japan
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Publication Date:
17 September 2002 (online)

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N-Substituted phthalimides were successfully hydrolyzed to the corresponding hydroxy-substituted aliphatic primary amines (amino alcohols) using anion exchange resins. This method has been proved to be extremely useful for water soluble products, which are difficult to isolate.