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Synthesis 2000; 2000(3): 329-351
DOI: 10.1055/s-2000-6333
review
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Synthesis of Acyclovir, Ganciclovir and Their Prodrugs: A Review

Hongwu Gao* , Ashim K. Mitra
  • *Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, 5050 Rockhill Road, Kansas City, MO 64110-2499, USA; Fax +1 (8 16) 2 35 51 90; E-mail: mitraa@umkc.edu
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Publikationsdatum:
31. Dezember 2000 (online)

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This review article deals with the synthetic methods of acyclovir, ganciclovir and their prodrugs. Based on the starting materials, three main routes to acyclovir and ganciclovir are described, including N 9-regioselective synthesis. Prodrug approaches to increase the bioavailability included esterification, phosphorylation of acyclic fragment and oxidation of 6-deoxy acyclovir by xanthine oxidase.

acyclovir - ganciclovir - synthesis - antiviral drugs - prodrugs - purines