Multiple Routes for the Synthesis of N-Acyl Sulfonamide-Bridged Nucleosides

Abstract

Methods are described for the synthesis of uridine nucleoside derivatives containing an α-3′′-methylenesulfonamide functionality. Several monomers possessing this functionality in both ribo- and deoxyribo-forms are detailed. Use of these monomers to construct the first N-acylsulfonamide-bridged dinucleoside is also described.

Key words

sulfonamide - sulfonimide - nucleosides - sulfonamide dianion - protecting groups

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