Synthesis 2005(11): 1775-1778  
DOI: 10.1055/s-2005-865318
PAPER
© Georg Thieme Verlag Stuttgart · New York

An Efficient Method for the Protection of Alcohols and Phenols by Using Hexamethyldisilazane in the Presence of Cupric Sulfate Pentahydrate under Neutral Reaction Conditions

Batool Akhlaghinia*, Sedigheh Tavakoli
Department of Chemistry, Damghan University of Basic Sciences, Damghan, Iran
Fax: +98(232)5244787; e-Mail: b_akhlaghinia@dubs.ac.ir;
Further Information

Publication History

Received 31 January 2005
Publication Date:
18 April 2005 (online)

Abstract

Alcohols and phenols are protected with hexamethyldi­silazane in the presence of cupric sulfate pentahydrate in good to excellent yields in acetonitrile. The method is highly selective for the conversion of primary alcohols in the presence of secondary and tertiary alcohols as well as phenols.