Towards the Syntheses of α-Trifluoromethylated Oxygenated Heterocycles and Their Precursors
20 July 2005 (eFirst)
The possibilities of synthesizing various α-trifluoromethylated oxygenated heterocycles, starting from trifluoroacetaldehyde methyl hemiacetal, through classic cyclization reactions, have been demonstrated. In this way, six-membered cyclic compounds, δ-lactones and also macrolactones, bearing a CF3 group in a position α to the oxygen could be easily obtained through a RCM reaction. Bicyclic compounds could be also synthesized by an intramolecular Pauson-Khand reaction.
fluorine - metathesis - cyclizations - oxygenated heterocycles - trifluoroacetaldehyde