Reduction of 2,5-Bis(3′-indolyl)pyrazines to 2,5-Bis(3′-indolyl)piperazines: Synthesis of Bisindolylpiperazine Marine Alkaloids Dragmacidin A, B, and C

Fay Tonsiengsom; Fumiko Y. Miyake; Kenichi Yakushijin; David A. Horne

doi:10.1055/s-2005-918431

PAPER

Reduction of 2,5-Bis(3′-indolyl)pyrazines to 2,5-Bis(3′-indolyl)piperazines: Synthesis of Bisindolylpiperazine Marine Alkaloids Dragmacidin A, B, and C

Fay Tonsiengsom, Fumiko Y. Miyake, Kenichi Yakushijin, David A. Horne*
Department of Chemistry, Oregon State University, Corvallis, OR 97333, USA
Fax: +1(541)7372062; e-Mail: horned@onid.orst.edu;

Abstract

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Abstract

A concise total synthesis of the bisindole alkaloids dragmacidin A, B and C is described that centers on the preparation and reduction of 2,5-bis(3′-indolyl)pyrazines to 2,5-bis(3′-indolyl)piperazines.

Key words

total synthesis - indoles - reductions - pyrazines - piperazines

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References

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