Abstract
The work deals with the effect of 5-hydroxytryptamine (5HT) on the isolated aortic
strip preparations obtained from untreated and reserpine treated rabbits. On the isolated
preparations obtained from the untreated (control) group 5HT was used in concentrations
of 20-160 ng/ml. On similar preparations obtained from the reserpine treated group
lower concentrations, i.e. 2.5-10 ng/ml, were required to induce contractile responses,
and contractions of significantly greater amplitude were produced by concentrations
used in the control group. These findings indicate that reserpinization increased
the sensitivity of the isolated aortic strip preparations to 5HT. Reserpine was administered
intraperitoneally in 0.3 mg/kg daily doses for three successive days to the test group
of animals.
Key Word Index
Reserpine - 5-Hydroxytryptamine - Aortic Strips
