Abstract
We present herein a review of multicomponent reactions of carbonyl compounds with
derivatives of cyanoacetic acid, and denote their differences from other well-known
multicomponent reactions. Although this class of multicomponent reactions is widely
used in organic chemistry for the synthesis of carbo- and heterocycles, it has not
yet been reviewed in a separate publication. This review includes available information
on the synthesis of carbocycles (substituted cyclopropanes, spiro-conjugated cyclopropanes,
five- and six-membered carbocycles), five-membered heterocycles (furans, thiophenes,
pyrroles, thiazoles, and others), and six-membered heterocycles (pyrans, thiopyrans,
and pyridines) using the multicomponent reaction of carbonyl compounds with derivatives
of cyanoacetic acid.
1 Introduction
2 Multicomponent Carbocyclic Synthesis
2.1 Synthesis of Cyclopropanes
2.2 Synthesis of Five- and Six-Membered Carbocycles
3 Multicomponent Heterocyclic Synthesis
3.1 Synthesis of Five-Membered Heterocycles
3.2 Synthesis of Six-Membered Heterocycles
4 Conclusion
Key words
multicomponent reactions - cyanoacetic acid derivatives - malononitrile - cyanothioacetamide
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