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Synthesis of Phomopsin B
J. S. Grimley, A. M. Sawayama, H. Tanaka, M. M. Stohlmeyer, T. F. Woiwode, T. J. Wandless*
Stanford University, USA
21 February 2008 (online)
Phomopsin B is a potent microtubule-destabilizing agent, isolated from the fungus Phomopsis leptostromiformis. In the present synthesis fully functionalized building blocks are combined by peptide coupling reactions followed by a late-stage macrocyclization. Phomopsin B was obtained after 26 steps.