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Synthesis of MK-0974
D. V. Paone et al.*
Merck Research Laboratories, West Point, USA
21 February 2008 (online)
Calcitonin gene-related peptide (CGRP) is a 37 amino acid neuropeptide found in the CNS periphery that is implicated in migraine. Interest in CGRB antagonism stems from the fact that it lacks a vasoconstrictive side effect. MK-0974 is a potent orally available CGRG receptor antagonist based on an aminocaprolactam template in phase II clinical trials for the treatment of migraine.