Synfacts 2008(3): 0225-0225  
DOI: 10.1055/s-2008-1042658
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of MK-0974

Contributor(s): Philip Kocienski
D. V. Paone et al.*
Merck Research Laboratories, West Point, USA
Further Information

Publication History

Publication Date:
21 February 2008 (online)


Calcitonin gene-related peptide (CGRP) is a 37 amino acid neuropeptide found in the CNS periphery that is implicated in migraine. Interest in CGRB antagonism stems from the fact that it lacks a vasoconstrictive side effect. MK-0974 is a potent orally available CGRG receptor antagonist based on an aminocaprolactam template in phase II clinical trials for the treatment of migraine.