Total Mycosynthesis: Rational Bioconstruction and Bioengineering of Fungal Natural Products

Lukas Kahlert; Carsten Schotte; Russell J. Cox

doi:10.1055/a-1401-2716

Synthesis, Table of Contents

Synthesis 2021; 53(14): 2381-2394
DOI: 10.1055/a-1401-2716

short review

Total Mycosynthesis: Rational Bioconstruction and Bioengineering of Fungal Natural Products

Lukas Kahlert‡

^aInstitute for Organic Chemistry, Leibniz University of Hannover, Schneiderberg 1a, 30167, Hannover, Germany

^bBMWZ, Schneiderberg 38, 30167, Hannover, Germany

,

Carsten Schotte‡

^aInstitute for Organic Chemistry, Leibniz University of Hannover, Schneiderberg 1a, 30167, Hannover, Germany

^bBMWZ, Schneiderberg 38, 30167, Hannover, Germany

,

Russell J. Cox ∗

^aInstitute for Organic Chemistry, Leibniz University of Hannover, Schneiderberg 1a, 30167, Hannover, Germany

^bBMWZ, Schneiderberg 38, 30167, Hannover, Germany

› Author Affiliations

Abstract

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Abstract

Total biosynthesis in fungi is beginning to compete with traditional chemical total synthesis campaigns. Herein, the advantages, disadvantages and future opportunities are discussed within the scope of several recent examples.

1 Introduction

2 Synthetic Examples

2.1 2-Pyridones

2.2 Cytochalasans

2.3 Sorbicillinoids

2.4 Decalins: Solanapyrone

2.5 α-Pyrone Polyenes: Citreoviridin and Aurovertin

2.6 Anditomin and Related Meroterpenoids

2.7 Tropolone Sesquiterpenoids

3 Conclusion

Key words

pyridone - cytochalasan - sorbicillinoid - decalin - α-pyrone - meroterpenoid - tropolone sesquiterpenoid

Full Text

References

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