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Synthesis 2022; 54(01): 210-216
DOI: 10.1055/a-1577-6344
DOI: 10.1055/a-1577-6344
paper
Mn(OAc)3 Induced C-4 Arylations of Quinazoline 3-Oxides with Arylboronic Acids
Bursa Uludağ University Research Fund is gratefully acknowledged for its financial support (Project No: DDP(F)-2020/6).
Abstract
The use of manganese triacetate as an oxidant component in the C-4 arylations of 2-aryl-quinazoline 3-oxides with arylboronic acids is reported. The new protocol was applied to prepare new 2,4-diarylated quinazoline 3-oxides in good to high yields. The method was shown to tolerate various substituents on both aromatic rings, and no complications such as deoxygenation or rearrangement to quinazolin-4(3H)-one was observed.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1577-6344.
- Supporting Information
Publication History
Received: 12 July 2021
Accepted after revision: 03 August 2021
Accepted Manuscript online:
03 August 2021
Article published online:
01 September 2021
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