Total Synthesis of Thiocladospolide A and Its C2-Epimer

Abstract

The first total synthesis of the recently isolated natural product thiocladospolide A, along with its C2-epimer, is achieved in nine straightforward linear steps and 12% overall yield. The key feature of the synthesis is the construction of the macrocyclic ring via a late-stage ring-closing metathesis reaction followed by alkene reduction.

Key words

total synthesis - macrolide - thiocladospolide A - sulfa-Michael­ addition - ring closing metathesis

Publication History

Received: 24 August 2021

Accepted after revision: 23 September 2021

Accepted Manuscript online:
23 September 2021

Article published online:
03 November 2021

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