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Synthesis 2022; 54(21): 4795-4801
DOI: 10.1055/a-1662-7096
DOI: 10.1055/a-1662-7096
special topic
Asymmetric C–H Functionalization
Asymmetric C–H Functionalization Enabled by Pd/Chiral Phosphoric Acid Combined Catalysis
We are grateful for financial support from the Ministry of Science and Technology of the People’s Republic of China (2015CB856600), the National Natural Science Foundation of China (NSFC, 21831007 and 21672197) and Youth Innovation Promotion Association of the Chinese Academy of Sciences is gratefully acknowledged.
Abstract
Over the past decade, the combination of chiral phosphoric acid and palladium catalysis has emerged as a robust strategy to accomplish the regio- and stereoselective functionalization of inactive C–H bonds, enabling access to various types of chirality (central, planar, and axial). This review article describes the origin and advances in the asymmetric functionalization of allylic C–H, C(sp2)–H, and C(sp3)–H bonds enabled by chiral phosphoric acid and palladium combined catalysis.
1 Introduction
2.1 Enantioselective Allylic C–H Functionalization
2.2 Enantioselective Non-allylic C(sp3)–H Functionalization
2.3 Enantioselective C(sp2)–H Functionalization
3 Conclusion
Key words
asymmetric catalysis - palladium catalysis - C–H activation - chiral phosphoric acid - combined catalysisPublication History
Received: 07 September 2021
Accepted after revision: 06 October 2021
Accepted Manuscript online:
06 October 2021
Article published online:
22 November 2021
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For early stoichiometric example, please see: