In this study, a synthetic approach is reported for generating hepta-branched β-cyclodextrins
(CDs) bearing heterogeneous carbohydrate residues at their primary side via a one-pot
process with a simultaneous click chemistry reaction. The reactions were performed
by reacting two or three different species of 2-propynylated glycosides with a hepta-azide
functional β-CD at various reaction molar ratios. 2-Propynylated glycosides acted
as heterogeneous carbohydrate sources embedded into a hepta-azide functional β-CD.
The simultaneous click chemistry reactions generated several desired β-CD derivatives
with varying densities of the heterogeneous carbohydrates in a one-pot process. The
article describes the effects of the combination of 2-propynylated glycosides and
the reaction molar ratios in the click chemistry reactions.
Key words
cyclodextrin - click chemistry reaction - carbohydrate-branched cyclodextrin - heteroglycoconjugate
- heterogeneous carbohydrate - simultaneous reaction