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Synlett 2025; 36(05): 541-545
DOI: 10.1055/a-2361-6916
DOI: 10.1055/a-2361-6916
letter
Synthesis and Biological Evaluation of Novel Coumarin Derivatives Bearing a Sulfonamide Moiety as Antiviral and Antibacterial Agent
The research is financially supported by the Science and Technology Planning Project of Guizhou Province (Grant No. Qian Ke He Ji Chu ZK [2022]Zhong Dian 025), the High School Science and Technology Talent Support Project of Guizhou Province, China (Grant No. Qian Jiao He KY Zi [2021]037), the Guizhou Industry Polytechnic College Science and Technology Innovation Team Project (Grant No. 2023CXTD03), the High-Level Talent Initial Funding of Guizhou Industry Polytechnic College (Grant No. 2023-RC-01), The Opening Foundation of the Key Laboratory of Green Pesticide and Agricultural Bioengineering, the Ministry of Education, Guizhou University (Grant No. Qian Jiao Ji [2022]433), the Academic New Seedling Cultivation and Exploration and Innovation Project of Guizhou Institute of Technology (No. GZLGXM-20), Guizhou Industry Polytechnic College Faculty-Level Research Project (Grant No. 2023ZK10 and Grant No. 2023ZK11).
Abstract
Twenty novel 4-bromocoumarin derivatives bearing a sulfonamide moiety were designed and synthesized. Their antiviral and antibacterial activities were systematically evaluated. The test results show that all the target compounds possess moderate to excellent antiviral and antibacterial activities. Among all target compounds, one compound exhibited good antiviral activity against TMV, CMV, and PVY, which is superior to ribavirin. Moreover, two target compounds exhibited good in vitro antibacterial activity against Psa, with an EC50 value of 44.9 mg/L and 49.3 mg/L, respectively, which were better than thiodiazole copper and zinc thiazole, with an EC50 value of 56.3 mg/L and 50.2 mg/L, respectively. The results provide insights for the development of multifunctional pesticides.
Key words
coumarin derivatives - antiviral activity - antibacterial activity - TMV - CMV - PVY - Xoo - PsaSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2361-6916. Included are the 1H NMR, 13C NMR, and HRMS spectra of synthesized compounds I1–I20.
- Supporting Information
Publication History
Received: 15 May 2024
Accepted after revision: 08 July 2024
Accepted Manuscript online:
08 July 2024
Article published online:
22 July 2024
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