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Synlett 2025; 36(09): 1272-1276
DOI: 10.1055/a-2518-6288
DOI: 10.1055/a-2518-6288
letter
Efficient Synthesis of N-Phenyl-4-(trifluoromethyl)thiazol-2-amine and Its Antibacterial Activity
We are grateful for the financial support from the National Natural Science Foundation of China (GZ-1645), the Key Research & Development Project in Shaanxi Province (2022GY-195, 2023-YBGY-183), the Basic Research Project of Natural Science of Shaanxi Province (2021JLM-30), and the Shaanxi Provincial Department of Education Science and Technology Project (23JC035).
Abstract
N-Phenyl-4-(trifluoromethyl) thiazole-2-amine is an important class of fluorinated heterocyclic compounds, particularly in the fields of fungicides and insecticides. However, there are very limited reports on the synthesis of such compounds. Here, we report a concise and efficient new method for synthesizing this thiazol-2-amine, which has good substrate versatility, strong functional group tolerance, and a single-product structure. The product structure and yield can be effectively and selectively controlled by adding or not adding alkali and other factors. Bactericidal activity tests showed that most of these compounds exhibit bactericidal activity, with the best bactericidal rate reaching 99%.
Key words
trifluoromethyl - thiazole-2-amine - phenylthiourea - transition-metal free - bactericidal activitySupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2518-6288.
- Supporting Information
Publikationsverlauf
Eingereicht: 10. Dezember 2024
Angenommen nach Revision: 16. Januar 2025
Accepted Manuscript online:
16. Januar 2025
Artikel online veröffentlicht:
12. März 2025
© 2025. Thieme. All rights reserved
Georg Thieme Verlag KG
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