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DOI: 10.1055/a-2538-2942
Rapid Assembly of Oxatricyclo[3.2.1.02,7]octanes
This work was supported by the National Natural Science Foundation of China (22201023, 22271242, and 22471232) and the Jiangsu Provincial Key Laboratory of Advanced Catalytic Materials and Technology Department, Jiangsu Provincial Department of Science and Technology (BM2012110).

Abstract
Cyclopropane-incorporated oxapolycyclic bridged molecules are often architecturally intriguing, synthetically useful, and biologically important. However, strategies for constructing such complex structures are relatively limited. This paper reviews representative methods that provide rapid access to a specific class of oxatricyclooctane frameworks containing cyclopropane, oxatricyclo[3.2.1.02,7]octane. A recent example of enantioselective construction of such a complex oxatricyclooctane structure is presented.
1 Introduction
2 Racemic Synthesis of Oxatricyclo[3.2.1.02,7]octanes
3 Enantioselective Synthesis of Oxatricyclo[3.2.1.02,7]octanes
4 Conclusion
Key words
cyclopropane - strained rings - cascade reaction - bridged molecules - molecular complexityPublication History
Received: 24 January 2025
Accepted after revision: 12 February 2025
Accepted Manuscript online:
12 February 2025
Article published online:
02 April 2025
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