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DOI: 10.1055/a-2695-8269
Reductive Monocarboxylation of Aryl Alkynes with CO2 via Electrochemistry
Authors
The authors gratefully acknowledge the financial support from the Start-up Fund from Nanjing Tech University (Grant Nos. 39837126).
Abstract
An electrochemical monocarboxylation of aryl alkynes with carbon dioxide to prepare acrylic acids and propionic acids has been developed. In a three-electrode electrochemical system, the reaction proceeds smoothly at a constant current in acetonitrile, which contains tetrabutylammonium bromide, and gives monocarboxylic acid products with up to 72% overall isolated yield. The system is applicable to terminal and internal aryl alkynes, exhibiting good functional group tolerance. This method may open up a window for the application of the electrochemical strategy in the synthesis of monocarboxylic acids from unsaturated hydrocarbons.
Keywords
Electrochemistry - Aryl alkynes - Reductive monocarboxylation - Carbon dioxide - Organic synthesisPublication History
Received: 17 July 2025
Accepted after revision: 04 September 2025
Accepted Manuscript online:
04 September 2025
Article published online:
01 October 2025
© 2025. Thieme. All rights reserved.
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